After the tremendous popular success of the Fantômas novels, both of the major French film studios — Pathé and Gaumont — vied for the rights to produce films based on the series. Gaumont won, and from April 1913 to May 1914 Louis Feuillade directed five Fantômas films which critic David Thomson has described as "the first great movie experience."
玛丽(凯特·哈德森 Kate Hudson 饰)是个开朗上进的大龄女青年,虽然年轻,但在公司很受高层器重,事业蒸蒸日上,虽然单身,但有许多好朋友,非常享受生活。但是不幸依旧降下,她被诊断患了癌症,更不可思议的是,伴随着厄运降临的还有爱情,她和主治医师、腼腆的西班牙裔小伙儿朱利安(盖尔·加西亚·贝纳尔 Gael García Bernal 饰)产生了感觉。开朗的性格让她笑对病痛,但难免会抑郁、绝望、诅咒命运的不公,一个又一个情绪期里面,对爱情的渴望和抗拒又同时存在。 死亡如约而至时,玛丽会选择以怎样的表情来面对……